CTLA-4 +49A>G polymorphism of recipients of HLA-matched sibling allogeneic stem cell transplantation is associated with survival and relapse incidence | Zendy

Patrizia Piccioli | Zendy; Giuseppe Balbi | Zendy; Martina Serra | Zendy; Anna Morabito | Zendy; Teresa Lamparelli | Zendy; Marco Gobbi | Zendy; Stefania Laurent | Zendy; Béatrice Dozin | Zendy; Paolo Bruzzi | Zendy; Anna Maria Ferraris | Zendy; Andrea Bacigalupo | Zendy; Rosario Notaro | Zendy; Maria Pia Pistillo | Zendy

Open Access

CTLA-4 +49A>G polymorphism of recipients of HLA-matched sibling allogeneic stem cell transplantation is associated with survival and relapse incidence

Author(s) -

Patrizia Piccioli,

Giuseppe Balbi,

Martina Serra,

Anna Morabito,

Teresa Lamparelli,

Marco Gobbi,

Stefania Laurent,

Béatrice Dozin,

Paolo Bruzzi,

Anna Maria Ferraris,

Andrea Bacigalupo,

Rosario Notaro,

Maria Pia Pistillo

Publication year - 2009

Publication title -

annals of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.079

H-Index - 80

eISSN - 1432-0584

pISSN - 0939-5555

DOI - 10.1007/s00277-009-0885-5

Subject(s) - hematopoietic stem cell transplantation , transplantation , sibling , medicine , hematology , genotype , stem cell , immunology , allele , human leukocyte antigen , oncology , gastroenterology , biology , gene , genetics , antigen , psychology , developmental psychology

Conflicting observations have been reported about the role of CTLA-4 gene polymorphisms in the clinical outcome of allogeneic hematopoietic stem cell transplantation (HSCT). We have investigated three polymorphisms of the CTLA-4 gene (-318C>T, +49A>G, CT60G>A) in 133 donor/recipient pairs who underwent HLA-matched sibling donor HSCT for hematological malignancies. We found no association of the clinical outcome of the HSCT with either recipient or donor -318C>T and CT60G>A polymorphisms. At variance, we found a significant association of donor +49A>G G/G genotype with longer overall survival (OS; log-rank test, P = 0.04), and the number of +49A>G G-alleles in the recipient with longer OS (P = 0.027), longer disease-free survival (P = 0.036) and reduced relapse rate (P = 0.042). However, only recipient +49A>G polymorphism was retained as independent prognostic factor in a multivariate analysis, suggesting that the expression of CTLA-4 on the cells of recipient may be relevant for the clinical outcome of HSCT.

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