Serum cytokines in follicular lymphoma. Correlation of TGF-β and VEGF with survival | Zendy

Sana Intidhar LabidiGaly | Zendy; Christine MénétrierCaux | Zendy; Sylvie Chabaud | Zendy; Catherine Chassagne | Zendy; Catherine Sebban | Zendy; Thérèse Gargi | Zendy; Pierre Biron | Zendy; JeanYves Blay | Zendy; Hervé Ghesquières | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Serum cytokines in follicular lymphoma. Correlation of TGF-β and VEGF with survival

Author(s) -

Sana Intidhar LabidiGaly,

Christine MénétrierCaux,

Sylvie Chabaud,

Catherine Chassagne,

Catherine Sebban,

Thérèse Gargi,

Pierre Biron,

JeanYves Blay,

Hervé Ghesquières

Publication year - 2009

Publication title -

annals of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.079

H-Index - 80

eISSN - 1432-0584

pISSN - 0939-5555

DOI - 10.1007/s00277-009-0777-8

Subject(s) - follicular lymphoma , vascular endothelial growth factor , medicine , transforming growth factor , hematology , lymphoma , tumor microenvironment , tumor necrosis factor alpha , cytokine , lactate dehydrogenase , endocrinology , immunology , cancer , biology , vegf receptors , biochemistry , enzyme

The prognosis of follicular lymphoma could vary with the tumor immune microenvironment. We evaluated the prognostic value of serum levels of ten cytokines. Our study cohort included 60 follicular lymphoma patients and 20 controls. Serum was available at diagnosis in 31 patients, at first relapse in 18, and complete remission in 11. Bioplex technology was used for determination of nine cytokines [interleukin (IL)-1Ra, IL-6, IL-7, IL-10, IL-13, tumor necrosis factor alpha (TNF-α), vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and basic fibroblast growth factor (b-FGF)]. Transforming growth factor beta (TGF-β) was measured by sandwich enzyme-linked immunosorbent assay. IL-1Ra, IL-6, IL-7, IL-10, IL-13, TNF-α, VEGF, and PDGF levels were found increased in follicular lymphoma patients compared to controls. Multivariate analysis identified early stage and high TGF-β levels as independent predictors of overall survival associated with improved outcome. High lactate dehydrogenase and VEGF levels were independently associated with poorer progression-free survival. These results show the prognostic value of TGF-β and VEGF in follicular lymphoma and suggest their contribution to tumor microenvironment alterations.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research