Open AccessEfficacy of the Oral Administration of Maltodextrin Fructose Before Major Abdominal Surgery: A Prospective, Multicenter Clinical Study
Author(s) -
Qin Huanlong,
Ji Jiafu,
Miao Yi,
Liu Tong,
Zhao Dongbing,
Jia Zhenyi,
Jiang Jun,
Liu Jiang,
Li Qiang,
Ji Xi,
Fu Weihua,
Lou Donghua,
Xia Wenyu,
Li Ning
Publication year - 2022
Publication title -
world journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.115
H-Index - 148
eISSN - 1432-2323
pISSN - 0364-2313
DOI - 10.1007/s00268-022-06455-7
Subject(s) - medicine , nausea , abdominal surgery , clinical endpoint , appetite , prospective cohort study , insulin , insulin resistance , gastroenterology , clinical trial , surgery , anesthesia
Background To study the efficacy of the oral administration of maltodextrin and fructose before major abdominal surgery (MAS). Methods This prospective, multicenter, parallel‐controlled, double‐blind study included patients aged 45–70 years who underwent elective gastrectomy, colorectal resection, or duodenopancreatectomy. The intervention group (IG) was given 800 mL and 400 mL of a maltodextrin and fructose beverage at 10 h and 2 h before MAS, respectively, and the control group (CG) received water under the same experimental conditions. The primary endpoint was insulin resistance index (IRI), and the secondary endpoints were fasting blood glucose, fasting insulin, insulin secretion index, insulin sensitivity index, intraoperative blood glucose, subjective comfort score, and clinical outcome indicators. Results A total of 240 cases were screened, of which 231 cases were randomly divided into two groups: 114 in the IG and 117 in the CG. No time‐treatment effect was detected for any endpoint. The IRI and fasting insulin were significantly lower in the IG than CG after MAS ( p = 0.02 & P = 0.03). The scores for anxiety, appetite, and nausea were significantly lower in the IG than CG at 1 h before MAS. Compared with baseline, the scores for appetite and nausea decreased in the IG but increased in the CG. Conclusion The oral administration of maltodextrin and fructose before MAS can improve preoperative subjective well‐being and reduce postoperative insulin resistance without increasing the risk of gastrointestinal discomfort.