Open AccessA Systematic Review and Meta‐analysis of Timing and Outcome of Intestinal Failure Surgery in Patients with Enteric Fistula
Author(s) -
Vries Fleur E. E.,
Atema Jasper J.,
Ruler Oddeke,
Vaizey Carolynne J.,
Serlie Mireille J.,
Boermeester Marja A.
Publication year - 2018
Publication title -
world journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.115
H-Index - 148
eISSN - 1432-2323
pISSN - 0364-2313
DOI - 10.1007/s00268-017-4224-z
Subject(s) - medicine , cardiac surgery , cardiothoracic surgery , vascular surgery , abdominal surgery , meta analysis , surgery , fistula , general surgery
Background The timing of intestinal failure (IF) surgery has changed. Most specialized centers now recommend postponing reconstructive surgery for enteric fistula and emphasize that abdominal sepsis has to be resolved and the patient’s condition improved. Our aim was to study the outcome of postponed surgery, to identify risk factors for recurrence and mortality, and to define more precisely the optimal timing of reconstructive surgery. Methods PubMed, Embase, and the Cochrane Library were systematically reviewed on the outcomes of reconstructive IF surgery (fistula recurrence, mortality, morbidity, hernia recurrence, total closure, enteral autonomy). If appropriate, meta‐analyses were performed. Optimal timing was explored, and risk factors for recurrence and mortality were identified. Results Fifteen studies were included. The weighted pooled fistula recurrence rate was 19% (95% CI 15–24). Lower recurrence rates were found in studies with a longer median time and/or, at the minimum of the range, a longer time interval to surgery. Overall mortality was 3% (95% CI 2–5). Total fistula closure rates ranged from 80 to 97%. Enteral autonomy after reconstructive surgery, mentioned in four studies, varied between 79 and 100%. Conclusions Postponed IF surgery for enteric fistula is associated with lower recurrence. Due to the wide range of time to definitive surgery within each study, optimal timing of surgery could not be defined from published data.