Open AccessA Novel Prognostic Scoring System Using Inflammatory Response Biomarkers for Esophageal Squamous Cell Carcinoma
Author(s) -
Hirahara Noriyuki,
Tajima Yoshitsugu,
Fujii Yusuke,
Yamamoto Tetsu,
Hyakudomi Ryoji,
Hirayama Takanori,
Taniura Takahito,
Ishitobi Kazunari,
Kidani Akihiko,
Kawabata Yasunari
Publication year - 2018
Publication title -
world journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.115
H-Index - 148
eISSN - 1432-2323
pISSN - 0364-2313
DOI - 10.1007/s00268-017-4144-y
Subject(s) - medicine , esophageal squamous cell carcinoma , esophagectomy , multivariate analysis , cardiothoracic surgery , univariate analysis , gastroenterology , neutrophil to lymphocyte ratio , vascular surgery , biomarker , carcinoma , lymphocyte , esophageal cancer , oncology , cardiac surgery , surgery , cancer , biochemistry , chemistry
Background We describe a novel scoring system, namely the inflammatory response biomarker (IRB) score. The aim of this study is to evaluate the clinical value of IRB score in patients undergoing curative resection for esophageal squamous cell carcinoma (SCC). Methods We retrospectively reviewed patients who underwent curative esophagectomy. We evaluated IRB score in both non‐elderly (<70 years) and elderly (≥70 years) SCC patients. The IRB score was determined as follows: a high lymphocyte‐to‐monocyte ratio (LMR) (>4), a high neutrophil‐to‐lymphocyte ratio (NLR) (>1.6), and a low platelet‐to‐lymphocyte ratio (PLR) (<147) were each scored as 1, and the remaining values were scored as 0; the individual scores were then summed to produce the IRB score (range 0−3). Results Univariate analyses demonstrated that the TNM pStage ( p < 0.0001), tumor size ( p = 0.002), LMR ( p = 0.0057), PLR ( p = 0.0328) and IRB score ( p = 0.0003) were significant risk factors for a worse prognosis. On multivariate analysis, the TNM pStage ( p < 0.0001) and IRB score ( p = 0.0227) were independently associated with worse prognosis in overall patients. Among non‐elderly patients, multivariate analyses demonstrated that the pStage ( p = 0.0015) and IRB score ( p = 0.0356) were independent risk factors for a worse prognosis. Among elderly patients, multivariate analysis demonstrated that the pStage ( p = 0.0016), and IRB score ( p = 0.0102) were independent risk factors for a worse prognosis. Conclusion The present study provides evidence that the preoperative IRB score can be considered a promising independent prognostic factor of cancer‐specific survival in patients undergoing curative resection for SCC, and that its predictive ability is useful in both non‐elderly and elderly patients.