Open AccessRoles and Mechanisms of MicroRNAs in Pancreatic Cancer
Author(s) -
Zhang Lidong,
Jamaluddin Md Saha,
Weakley Sarah M.,
Yao Qizhi,
Chen Changyi
Publication year - 2011
Publication title -
world journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.115
H-Index - 148
eISSN - 1432-2323
pISSN - 0364-2313
DOI - 10.1007/s00268-010-0952-z
Subject(s) - microrna , pancreatic cancer , malignancy , cancer , medicine , disease , bioinformatics , cancer research , biology , pathology , gene , genetics
Pancreatic cancer (PC) is an aggressive malignancy with poor survival. The discovery of microRNAs (miRNAs) has provided a new opportunity to study the disease. Thus far, altered expression of miRNAs has been reported in a wide range of malignancies, including PC, and some miRNAs are associated with PC cell proliferation, invasion, chemoresistance, and patient survival. This review summarizes recent advances with respect to the roles and mechanisms of miRNAs in PC and discusses potential clinical applications.