Open AccessDeveloping a Tissue Resource to Characterize the Genome of Pancreatic Cancer
Author(s) -
Voidonikolas Georgios,
Gingras MarieClaude,
Hodges Sally,
McGuire Amy L.,
Chen Changyi,
Gibbs Richard A.,
Brunicardi F. Charles,
Fisher William E.
Publication year - 2009
Publication title -
world journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.115
H-Index - 148
eISSN - 1432-2323
pISSN - 0364-2313
DOI - 10.1007/s00268-008-9877-1
Subject(s) - pancreatic cancer , personalized medicine , disease , genome , computational biology , human genome , medicine , modalities , cancer , bioinformatics , data science , computer science , biology , pathology , gene , genetics , social science , sociology
With recent advances in DNA sequencing technology, medicine is entering an era in which a personalized genomic approach to diagnosis and treatment of disease is feasible. However, discovering the role of altered DNA sequences in various disease states will be a challenging task. The genomic approach offers great promise for diseases, such as pancreatic cancer, in which the effect of current diagnostic and treatment modalities is disappointing. To facilitate the characterization of the genome of pancreatic cancer, high‐quality and well‐annotated tissue repositories are needed. This article summarizes the basic principles that guide the creation of such a repository, including sample processing and preservation techniques, sample size and composition, and collection of clinical data elements.