Open AccessIDH mutation is paradoxically associated with higher 18F-FDOPA PET uptake in diffuse grade II and grade III gliomas
Author(s) -
Antoine Verger,
P. Métellus,
Quentin Sala,
Carole Colin,
Emilie Bialecki,
David Taïeb,
Olivier Chinot,
Dominique FigarellaBranger,
Éric Guedj
Publication year - 2017
Publication title -
european journal of nuclear medicine and molecular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.313
H-Index - 163
eISSN - 1619-7089
pISSN - 1619-7070
DOI - 10.1007/s00259-017-3668-6
Subject(s) - medicine , standardized uptake value , oligodendroglial tumor , mutation , positron emission tomography , nuclear medicine , glioma , oncology , oligodendroglioma , astrocytoma , cancer research , biology , gene , biochemistry
The World Health Organization Classification of Tumors of the Central Nervous System has recently been updated by the integration of diagnostic and prognostic molecular parameters, giving pivotal attention to IDH mutation as a favourable factor. Amino acid PET is increasingly used in the management of gliomas, but its prognostic value is a matter of debate. The aim of this study was to assess the relationship between IDH mutation and 18 F-FDOPA uptake on PET in newly diagnosed gliomas.
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