How do different extracorporeal circulation systems affect metoprolol bioavailability in coronary artery bypass surgery patients | Zendy

Hannu Kokki | Zendy; M. Maaroos | Zendy; Sten Ellam | Zendy; Jari Halonen | Zendy; Ilkka Ojanperä | Zendy; Merja Ranta | Zendy; VeliPekka Ranta | Zendy; Aleksandra Tolonen | Zendy; Oscar Lindberg | Zendy; Matias Viitala | Zendy; Juha Hartikainen | Zendy

Open Access

How do different extracorporeal circulation systems affect metoprolol bioavailability in coronary artery bypass surgery patients

Author(s) -

Hannu Kokki,

M. Maaroos,

Sten Ellam,

Jari Halonen,

Ilkka Ojanperä,

Merja Ranta,

VeliPekka Ranta,

Aleksandra Tolonen,

Oscar Lindberg,

Matias Viitala,

Juha Hartikainen

Publication year - 2018

Publication title -

european journal of clinical pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.845

H-Index - 108

eISSN - 1432-1041

pISSN - 0031-6970

DOI - 10.1007/s00228-018-2437-1

Subject(s) - bioavailability , metoprolol , medicine , extracorporeal circulation , anesthesia , coronary artery bypass surgery , atrial fibrillation , surgery , artery , pharmacology

Cardiac surgery and conventional extracorporeal circulation (CECC) impair the bioavailability of drugs administered by mouth. It is not known whether miniaturized ECC (MECC) or off-pump surgery (OPCAB) affect the bioavailability in similar manner. We evaluated the metoprolol bioavailability in patients undergoing CABG surgery with CECC, MECC, or having OPCAB.

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