Open AccessTwo separate dose-dependent effects of paroxetine: mydriasis and inhibition of tramadol’s O-demethylation via CYP2D6
Author(s) -
Anette Green Nielsen,
Rasmus S. Pedersen,
Lene NoehrJensen,
Per Damkier,
Kim Brøsen
Publication year - 2010
Publication title -
european journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 108
eISSN - 1432-1041
pISSN - 0031-6970
DOI - 10.1007/s00228-010-0803-8
Subject(s) - tramadol , placebo , bedtime , medicine , anesthesia , urine , ingestion , cyp2d6 , paroxetine , pharmacology , analgesic , metabolism , cytochrome p450 , alternative medicine , pathology , hippocampus , antidepressant
To investigate paroxetine's putative dose-dependent impact on pupil reaction and inhibition of the O-demethylation of tramadol.
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