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Evolution of nucleic acids biosensors detection limit III
Author(s) -
Yuan Yuan Zhang,
FrançoisXavier Guillon,
Sophie Griveau,
Fethi Bédioui,
Mathieu Lazerges,
Cyrine Slim
Publication year - 2021
Publication title -
analytical and bioanalytical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.86
H-Index - 166
eISSN - 1618-2650
pISSN - 1618-2642
DOI - 10.1007/s00216-021-03722-9
Subject(s) - nucleic acid , detection limit , biosensor , nanotechnology , computational biology , nucleic acid detection , dna , nucleic acid quantitation , transduction (biophysics) , limit (mathematics) , chemistry , biology , biochemistry , materials science , chromatography , mathematics , mathematical analysis
This review is an update of two previous ones focusing on the limit of detection of electrochemical nucleic acid biosensors allowing direct detection of nucleic acid target (miRNA, mRNA, DNA) after hybridization event. A classification founded on the nature of the electrochemical transduction pathway is established. It provides an overall picture of the detection limit evolution of the various sensor architectures developed during the last three decades and a critical report of recent strategies.

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