Ultra-high-resolution ion mobility spectrometry—current instrumentation, limitations, and future developments | Zendy

Ansgar T. Kirk | Zendy; Alexander Bohnhorst | Zendy; ChristianRobert Raddatz | Zendy; Maria Allers | Zendy; Stefan Zimmermann | Zendy

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Ultra-high-resolution ion mobility spectrometry—current instrumentation, limitations, and future developments

Author(s) -

Ansgar T. Kirk,

Alexander Bohnhorst,

ChristianRobert Raddatz,

Maria Allers,

Stefan Zimmermann

Publication year - 2019

Publication title -

analytical and bioanalytical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.86

H-Index - 166

eISSN - 1618-2650

pISSN - 1618-2642

DOI - 10.1007/s00216-019-01807-0

Subject(s) - ion mobility spectrometry , instrumentation (computer programming) , spectrometer , mass spectrometry , ion current , detector , explosive material , nanotechnology , resolution (logic) , current (fluid) , chemistry , analytical chemistry (journal) , computer science , materials science , physics , electrical engineering , engineering , telecommunications , optics , organic chemistry , chromatography , operating system , artificial intelligence

With recent advances in ionization sources and instrumentation, ion mobility spectrometers (IMS) have transformed from a detector for chemical warfare agents and explosives to a widely used tool in analytical and bioanalytical applications. This increasing measurement task complexity requires higher and higher analytical performance and especially ultra-high resolution. In this review, we will discuss the currently used ion mobility spectrometers able to reach such ultra-high resolution, defined here as a resolving power greater than 200. These instruments are drift tube IMS, traveling wave IMS, trapped IMS, and field asymmetric or differential IMS. The basic operating principles and the resulting effects of experimental parameters on resolving power are explained and compared between the different instruments. This allows understanding the current limitations of resolving power and how ion mobility spectrometers may progress in the future. Graphical abstract.

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