The effect of neuroleptic medication on prepulse inhibition in schizophrenia patients: current status and future issues | Zendy

Alfons O. Hamm | Zendy; Almut I. Weike | Zendy; Harald T. Schupp | Zendy

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The effect of neuroleptic medication on prepulse inhibition in schizophrenia patients: current status and future issues

Author(s) -

Alfons O. Hamm,

Almut I. Weike,

Harald T. Schupp

Publication year - 2001

Publication title -

psychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.378

H-Index - 196

eISSN - 1432-2072

pISSN - 0033-3158

DOI - 10.1007/s002130100827

Subject(s) - prepulse inhibition , schizophrenia (object oriented programming) , antipsychotic , psychology , psychosis , moro reflex , endophenotype , medicine , psychiatry , clinical psychology , reflex , neuroscience , cognition

Prepulse inhibition (PPI) of the startle reflex is a powerful tool for investigating sensorimotor gating in both animals and humans. Evidence of impaired PPI in patients with schizophrenia suggests that PPI performance might serve as a promising model to investigate the neurobiological mechanisms of this disorder. Animal data show that experimentally induced PPI deficits can be removed by the administration of antipsychotic agents. Recent clinical studies suggest that neuroleptic medication is capable of improving deficient PPI performance in schizophrenia patients as well.

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