Open AccessBisphosphonates alter trabecular bone collagen cross-linking and isomerization in beagle dog vertebra
Author(s) -
Matthew R. Allen,
Évelyne Gineyts,
Diana Julie Leeming,
David B. Burr,
Pierre D. Delmas
Publication year - 2007
Publication title -
osteoporosis international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 170
eISSN - 1433-2965
pISSN - 0937-941X
DOI - 10.1007/s00198-007-0533-7
Subject(s) - pyridinoline , bone remodeling , pentosidine , medicine , deoxypyridinoline , endocrinology , bisphosphonate , osteoporosis , raloxifene , beagle , type i collagen , chemistry , osteocalcin , biochemistry , tamoxifen , alkaline phosphatase , receptor , cancer , glycation , breast cancer , enzyme
Changes in organic matrix may contribute to the anti-fracture efficacy of anti-remodeling agents. Following one year of treatment in beagle dogs, bisphosphonates alter the organic matrix of vertebral trabecular bone, while raloxifene had no effect. These results show that pharmacological suppression of turnover alters the organic matrix component of bone.
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