Open AccessMapping functions in health‐related quality of life: mapping from the Achilles Tendon Rupture Score to the EQ‐5D
Author(s) -
Hua AyYen,
Westin Olof,
Hamrin Senorski Eric,
Svantesson Eleonor,
Grassi Alberto,
Zaffagnini Stefano,
Samuelsson Kristian,
Svensson Mikael
Publication year - 2018
Publication title -
knee surgery, sports traumatology, arthroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.806
H-Index - 125
eISSN - 1433-7347
pISSN - 0942-2056
DOI - 10.1007/s00167-018-4954-y
Subject(s) - achilles tendon , medicine , quality of life (healthcare) , preference , metric (unit) , physical therapy , dimension (graph theory) , tendon , surgery , statistics , mathematics , operations management , economics , nursing , pure mathematics
Purpose Health state utility values are derived from preference‐based measurements and are useful in calculating quality‐adjusted life years (QALYs), which is a metric commonly used in cost‐effectiveness studies. The purpose of this study was to convert the Achilles Tendon Rupture Score (ATRS) to the preference‐based European Quality of Life‐5 Dimension Questionnaire (EQ‐5D) by estimating the relationship between the two scores using mapping. Methods Data were collected from a randomised controlled trial, where 100 patients were treated either surgically or non‐surgically for Achilles tendon rupture. Forty‐three and forty‐four patients in surgical group and non‐surgical group completed the ATRS and the EQ‐5D alongside each other during follow‐up at three time points. Different models of the relationship between the ATRS and the EQ‐5D were developed and analysed based on direct mapping and cross‐validation. The model with the lowest mean absolute error was observed as the one with the best fit. Results Among the competing models, mapping based on using a combination of the ATRS items four, five, and six associated with limitation due to pain, during activities of daily living and when walking on uneven ground, produced the best predictor of the EQ‐5D score. Conclusions The present study provides a mapping algorithm to enable the derivation of utility values directly from the ATRS. This approach makes it feasible for researchers, as well as medical practitioners, to obtain preference‐based values in clinical studies or settings where only the ATRS is being administered. The algorithm allows for the calculation of QALYs for use in cost‐effectiveness analyses, making it valuable in the study of acute Achilles tendon ruptures. Level of evidence II.