Open AccessCYP1A/Regucalcin Gene Expression and Edema Formation in Zebrafish Embryos Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin
Author(s) -
YanLing Wu,
Lingling Jiang,
Zhen Zhou,
M.-H Zheng,
J. Zhang,
Yong Liang
Publication year - 2008
Publication title -
bulletin of environmental contamination and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.543
H-Index - 70
eISSN - 1432-0800
pISSN - 0007-4861
DOI - 10.1007/s00128-008-9395-8
Subject(s) - zebrafish , toxicity , tetrachlorodibenzo p dioxin , embryo , developmental toxicity , edema , andrology , gene expression , biology , ecotoxicology , gene , medicine , endocrinology , toxicology , chemistry , microbiology and biotechnology , biochemistry , genetics , pregnancy , gestation
In this study, zebrafish eggs were exposed to a relatively low concentration (50 pg/mL) of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) for 72 h and then transferred to vehicle/TCDD-free water for the remainder of the experiments. Mortality, heart rates, edema severity, CYP1A, and regucalcin gene expressions were investigated to study TCDD-induced toxicity in zebrafish during the early life stage. Results indicated that the 50 pg/mL TCDD caused severe and visible developmental toxicity. Further research of the long term and low concentration of TCDD exposure is required.
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