Hyaluronan suppresses mechanical stress-induced expression of catabolic enzymes by human chondrocytes via inhibition of IL-1β production and subsequent NF-κB activation | Zendy

Masatsugu Ozawa | Zendy; Keiichiro Nishida | Zendy; Aki Yoshida | Zendy; Taichi Saito | Zendy; Ryozo Harada | Zendy; Takahiro Machida | Zendy; Toshifumi Ozaki | Zendy

Open Access

Hyaluronan suppresses mechanical stress-induced expression of catabolic enzymes by human chondrocytes via inhibition of IL-1β production and subsequent NF-κB activation

Author(s) -

Masatsugu Ozawa,

Keiichiro Nishida,

Aki Yoshida,

Taichi Saito,

Ryozo Harada,

Takahiro Machida,

Toshifumi Ozaki

Publication year - 2015

Publication title -

inflammation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.121

H-Index - 89

eISSN - 1420-908X

pISSN - 1023-3830

DOI - 10.1007/s00011-015-0804-2

Subject(s) - adamts , immunocytochemistry , chemistry , microbiology and biotechnology , iκbα , nf κb , matrix metalloproteinase , blot , metalloproteinase , signal transduction , thrombospondin , biology , biochemistry , endocrinology , gene

To investigate the inhibitory effect of hyaluronan (HA) on mechanical stress- induced expression of a disintegrin and metalloproteinase with thrombospondin type 1 motifs (ADAMTS)-4, -5 and matrix metalloproteinase (MMP)-13 by human chondrocytes.

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