Open AccessPreparation and characterization of water-dispersible silver nanoparticles stabilized by PEO-conjugated pro-drugs
Author(s) -
Taehwan Kim,
Keunsuk Kim,
Geon Hee Park,
Jinhee Choi,
SangMi Lee,
Ho Jung Kang,
Jae Yeol Lee,
Jungahn Kim
Publication year - 2009
Publication title -
macromolecular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.491
H-Index - 49
eISSN - 2092-7673
pISSN - 1598-5032
DOI - 10.1007/bf03218613
Subject(s) - conjugated system , materials science , ethylene oxide , surface modification , nanochemistry , polymer chemistry , polymerization , monomer , organic chemistry , nuclear chemistry , copolymer , polymer , chemical engineering , chemistry , nanotechnology , engineering , composite material
ω-Anhydride-functionalized poly(ethylene oxide) (PEO) obtained from chain-end functionalization and anionic ring-opening polymerization of ethylene oxide usingn-butyllithium with potassiumt-butoxide in the presence of dimethylsulfoxide (DMSO) was found to be an efficient material for the preparation of water-soluble, polymeric pro-drugs. The reaction of ω-anhydride-functionalized PEO with sulfonamide or with vancomycin provided an efficient method to produce corresponding, water-soluble, PEO-conjugated sulfonamide or PEO-conjugated, vancomycin pro-drugs. These were used successfully to prepare water-dispersible, silver nanoparticles. In this study, the particle sizes were in the range of 5∼40 nm. The resulting products were characterized by1H NMR spectroscopy, transmission electron microscopy, electron and X-ray diffraction, size exclusion chromatography, and UV/Visible spectroscopy.
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