Potential biochemical markers for infantile autism | Zendy

Porn P. Israngkun | Zendy; Howard Newman | Zendy; Suman Patel | Zendy; Valentine A. Duruibe | Zendy; Hussein AbouIssa | Zendy

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Potential biochemical markers for infantile autism

Author(s) -

Porn P. Israngkun,

Howard Newman,

Suman Patel,

Valentine A. Duruibe,

Hussein AbouIssa

Publication year - 1986

Publication title -

neurochemical pathology

Language(s) - English

Resource type - Journals

eISSN - 2168-8664

pISSN - 0734-600X

DOI - 10.1007/bf03028036

Subject(s) - autism , dopamine , high performance liquid chromatography , medicine , endocrinology , epinephrine , sephadex , urine , serotonin , norepinephrine , chemistry , chromatography , biochemistry , psychiatry , enzyme , receptor

Biochemical markers are crucial to the development of early diagnosis of infantile autism. The blood concentrations of neuroanalytes epinephrine, norepinephrine, dopamine, and serotonin were elevated in autistic subjects (n = 13) as compared to normal controls (n = 10). Autistic subjects had peptide patterns (peaks I-V, Sephadex G-25) that were different from those of normal controls. Methionine-enkephalin has been tentatively identified from fraction I of autistic subjects by HPLC as one of a large number of peptides that appears to be elevated. The HPLC chromatographic patterns of fraction V from all autistic subjects show a peak with retention time of 7.6 min. The HPLC of control urine fraction V revealed no comparable peaks.

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