Microwave assisted wolff rearrangement: A facile method for the synthesis of Fmoc-β-amino acids | Zendy

Basanagoud S. Patil | Zendy; GangaRamu Vasanthakumar | Zendy; Vommina V. Suresh Babu | Zendy

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Microwave assisted wolff rearrangement: A facile method for the synthesis of Fmoc-β-amino acids

Author(s) -

Basanagoud S. Patil,

GangaRamu Vasanthakumar,

Vommina V. Suresh Babu

Publication year - 2002

Publication title -

letters in peptide science

Language(s) - English

Resource type - Journals

eISSN - 1573-496X

pISSN - 0929-5666

DOI - 10.1007/bf02538389

Subject(s) - chemistry , wolff rearrangement , amino acid , microwave irradiation , yield (engineering) , base (topology) , microwave , combinatorial chemistry , organic chemistry , biochemistry , catalysis , mathematical analysis , materials science , ketene , mathematics , physics , quantum mechanics , metallurgy

The Wolff rearrangement of α-diazoketones, derived from Fmoc-α-amino acids, under no base conditions on exposure to microwave irradiation for 40 to 60 sec to Fmoc-β-amino acids with retention of configuration in good yield (91-95%) is described

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