Prevalence of diffuse pancreatic beta islet cell disease with hyperinsulinism: Problems in recognition and management | Zendy

Harrison Timothy S. | Zendy; Fajans Stefan S. | Zendy; Floyd John C. | Zendy; Thompson Norman W. | Zendy; Rasbach Dennis A. | Zendy; Santen Richard J. | Zendy; Cohen Cynthia | Zendy

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Prevalence of diffuse pancreatic beta islet cell disease with hyperinsulinism: Problems in recognition and management

Author(s) -

Harrison Timothy S.,

Fajans Stefan S.,

Floyd John C.,

Thompson Norman W.,

Rasbach Dennis A.,

Santen Richard J.,

Cohen Cynthia

Publication year - 1984

Publication title -

world journal of surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.115

H-Index - 148

eISSN - 1432-2323

pISSN - 0364-2313

DOI - 10.1007/bf01654942

Subject(s) - nesidioblastosis , medicine , islet , hyperinsulinism , pancreas , hyperplasia , hyperinsulinemic hypoglycemia , pathology , disease , diabetes mellitus , gastroenterology , hypoglycemia , endocrinology , insulin resistance

Among 77 patients with endogenous hyperinsulinism seen in 2 medical centers, diffuse islet cell disease accounted for 17 (22%) patients. Since diffuse islet cell disease poses special problems in management, its prevalence is emphasized in this report. Among these patients with diffuse islet cell disease, there were 11 patients with adenomatosis, 4 with nesidioblastosis, and 2 with islet cell hyperplasia. Six of the 77 patients were found in multiple endocrine neoplasia, type I kindreds; diffuse islet cell disease was documented in 4 of these patients. We outline principles of management in patients with diffuse islet cell disease. Frozen section microscopy failed to identify nesidioblastosis or islet cell hyperplasia.

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