Segmental differences along the crypt axis in the response of cell volume to secretagogues or hypotonic medium in the rat colon | Zendy

Martin Diener | Zendy

Open Access

Segmental differences along the crypt axis in the response of cell volume to secretagogues or hypotonic medium in the rat colon

Author(s) -

Martin Diener

Publication year - 1994

Publication title -

pflügers archiv - european journal of physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.428

H-Index - 129

eISSN - 0365-267X

pISSN - 0031-6768

DOI - 10.1007/bf00388312

Subject(s) - crypt , cotransporter , tonicity , shrinkage , bumetanide , chemistry , fundus (uterus) , volume (thermodynamics) , anatomy , medicine , biology , endocrinology , biophysics , sodium , materials science , physics , surgery , organic chemistry , quantum mechanics , composite material

VIP caused a decrease in the diameter of rat colonic crypts. This decrease was followed by a volume increase at the middle and the upper third of the crypt, which finally led to an increase of crypt diameter above the initial control values. At the fundus only a cell shrinkage was observed. The volume increase at the upper parts of the crypt was suppressed by the inhibitor of the Na(+)-K(+)-Cl(-)-cotransporter, furosemide. When crypts were exposed to a hypertonic medium, cell shrinkage was followed by a regulatory volume increase at the middle and the upper third of the crypt but not at the fundus region. These results suggest a gradient in the distribution of the Na(+)-K(+)-Cl(-)-cotransporter along the crypt axis.

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