New gene in the homologous human 11q13?q14 and mouse 7F chromosomal regions | Zendy

Vincent Ollendorff | Zendy; Pierre Szepetowski | Zendy; Marie-Genevi�re Mattei | Zendy; Patrick Gaudray | Zendy; Daniel Birnbaum | Zendy

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New gene in the homologous human 11q13?q14 and mouse 7F chromosomal regions

Author(s) -

Vincent Ollendorff,

Pierre Szepetowski,

Marie-Genevi�re Mattei,

Patrick Gaudray,

Daniel Birnbaum

Publication year - 1992

Publication title -

mammalian genome

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.186

H-Index - 99

eISSN - 1432-1777

pISSN - 0938-8990

DOI - 10.1007/bf00302877

Subject(s) - biology , homology (biology) , gene , genetics , synteny , homologous chromosome , homologous recombination , conserved sequence , human genetics , cloning (programming) , chromosome , sequence analysis , chromosomal region , peptide sequence , computer science , programming language

Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies in which most of the key genes remain to be identified. In an effort to isolate as many candidates as possible, we are cloning genes from this region. We report here the mapping of a new sequence from 11q13.5-11q14. This sequence, designated D11S833E, putatively encodes a new gene, provisionally named GARP. We cloned its homologous sequence in the mouse and located it on Chromosome (Chr) 7, region F. The human and mouse genes belong to a conserved group of synteny. This, together with the similar conservation of the FGF and TYR genes, indicates that the human 11q13-q14 and mouse 7E-7F regions share homology.

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