Dynamic characteristics of serotonin and dopamine metabolism in the rainbow trout brain: a regional study using liquid chromatography with electrochemical detection | Zendy

Christian Saligaut | Zendy; Thierry Bailhache | Zendy; Gilles Salbert | Zendy; Bernard Breton | Zendy; P. Jégo | Zendy

Open Access

Dynamic characteristics of serotonin and dopamine metabolism in the rainbow trout brain: a regional study using liquid chromatography with electrochemical detection

Author(s) -

Christian Saligaut,

Thierry Bailhache,

Gilles Salbert,

Bernard Breton,

P. Jégo

Publication year - 1990

Publication title -

fish physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.68

H-Index - 79

eISSN - 1573-5168

pISSN - 0920-1742

DOI - 10.1007/bf00004458

Subject(s) - endocrinology , medicine , dopaminergic , dopamine , cerebrum , hypothalamus , biology , serotonin , rainbow trout , 5 ht receptor , catabolite repression , monoamine oxidase , biochemistry , central nervous system , enzyme , receptor , fishery , fish <actinopterygii> , mutant , gene

Aminergic metabolism was studied in discrete brain regions of the postovulated female rainbow trout using a liquid chromatography electrochemical detection method. 3 Methoxytyramine (3MT) was the major dopaminergic catabolite, suggesting that catechol-o-methyl transferase is the main dopamine (DA) catabolic enzyme. Two populations of brain regions were found: one with a high DA content and low 3MT/DA ratio (hypothalamus and telencephalon), suggesting that these regions could present a high density of DA perikarya; the other with a high 3MT/DA ratio (pituitary, preoptic area, myelencephalon and optic tectum) suggesting that these regions could present a high density of DA axonal endings. 5 Hydroxytryptamine (5HT) content differed, but an homogeneous distribution of monoamine oxidase was found in different brain regions. High 5HT content was found in the hypothalamus and telencephalon; 5HT was however not detectable in the pituitary.

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