Actin Filament Structures in Migrating Cells | Zendy

Jaakko Lehtimäki | Zendy; Markku Hakala | Zendy; Pekka Lappalainen | Zendy

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Actin Filament Structures in Migrating Cells

Author(s) -

Jaakko Lehtimäki,

Markku Hakala,

Pekka Lappalainen

Publication year - 2016

Publication title -

handbook of experimental pharmacology

Language(s) - English

Resource type - Book series

SCImago Journal Rank - 1.605

H-Index - 90

eISSN - 1865-0325

pISSN - 0171-2004

DOI - 10.1007/164_2016_28

Subject(s) - cell migration , actin , multicellular organism , protein filament , microbiology and biotechnology , actin remodeling , biology , actin binding protein , cell , intermediate filament , cytoskeleton , actin cytoskeleton , chemistry , biochemistry

Cell migration is necessary for several developmental processes in multicellular organisms. Furthermore, many physiological processes such as wound healing and immunological events in adult animals are dependent on cell migration. Consequently, defects in cell migration are linked to various diseases including immunological disorders as well as cancer progression and metastasis formation. Cell migration is driven by specific protrusive and contractile actin filament structures, but the types and relative contributions of these actin filament arrays vary depending on the cell type and the environment of the cell. In this chapter, we introduce the most important actin filament structures that contribute to mesenchymal and amoeboid cell migration modes and discuss the mechanisms by which the assembly and turnover of these structures are controlled by various actin-binding proteins.

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