EPR in Protein Science | Zendy

Malte Drescher | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

EPR in Protein Science

Author(s) -

Malte Drescher

Publication year - 2011

Publication title -

topics in current chemistry

Language(s) - English

Resource type - Book series

SCImago Journal Rank - 1.944

H-Index - 96

eISSN - 1436-5049

pISSN - 0340-1022

DOI - 10.1007/128_2011_235

Subject(s) - electron paramagnetic resonance , site directed spin labeling , flexibility (engineering) , electron paramagnetic resonance spectroscopy , chemistry , nuclear magnetic resonance , biophysics , physics , biology , mathematics , statistics

Intrinsically disordered proteins (IDPs) form a unique protein category characterized by the absence of a well-defined structure and by remarkable conformational flexibility. Electron Paramagnetic Resonance (EPR) spectroscopy combined with site-directed spin labeling (SDSL) is amongst the most suitable methods to unravel their structure and dynamics. This review summarizes the tremendous methodological developments in the area of SDSL EPR and its applications in protein research. Recent results on the intrinsically disordered Parkinson's disease protein α-synuclein illustrate that the method has gained increasing attention in IDP research. SDSL EPR has now reached a level where broad application in this rapidly advancing field is feasible.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research