Open AccessRegulatory gene network circuits underlying T cell development from multipotent progenitors
Author(s) -
Kueh Hao Yuan,
Rothenberg Ellen V.
Publication year - 2011
Publication title -
wiley interdisciplinary reviews: systems biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.087
H-Index - 51
eISSN - 1939-005X
pISSN - 1939-5094
DOI - 10.1002/wsbm.162
Subject(s) - progenitor cell , gene regulatory network , biology , cell fate determination , function (biology) , multipotent stem cell , gene , progenitor , stem cell , microbiology and biotechnology , regulation of gene expression , computational biology , neuroscience , gene expression , genetics , transcription factor
Regulatory gene circuits enable stem and progenitor cells to detect and process developmental signals and make irreversible fate commitment decisions. To gain insight into the gene circuits underlying T cell fate decision making in progenitor cells, we generated an updated T‐lymphocyte developmental gene regulatory network from genes and connections found in the literature. This reconstruction allowed us to identify candidate regulatory gene circuit elements underlying T cell fate decision making. Here, we examine the roles of these circuits in facilitating different aspects of the decision making process, and discuss experiments to further probe their structure and function. WIREs Syst Biol Med 2012, 4:79–102. doi: 10.1002/wsbm.162 This article is categorized under: Developmental Biology > Lineages