Systems biology of oxygen homeostasis | Zendy

Samanta Debangshu | Zendy; Prabhakar Nanduri R. | Zendy; Semenza Gregg L. | Zendy

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Systems biology of oxygen homeostasis

Author(s) -

Samanta Debangshu,

Prabhakar Nanduri R.,

Semenza Gregg L.

Publication year - 2017

Publication title -

wiley interdisciplinary reviews: systems biology and medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.087

H-Index - 51

eISSN - 1939-005X

pISSN - 1939-5094

DOI - 10.1002/wsbm.1382

Subject(s) - homeostasis , hypoxia (environmental) , cell physiology , biology , physiology , human physiology , microbiology and biotechnology , oxygen metabolism , bioinformatics , cell , oxygen , chemistry , genetics , endocrinology , organic chemistry

Metazoan species maintain oxygen homeostasis through the activity of hypoxia‐inducible factors, which are transcriptional activators that regulate the expression of hundreds of genes to match O 2 supply and demand. Here, we review the involvement of hypoxia‐inducible factors in the molecular physiology and pathophysiology of cellular O 2 sensing, O 2 delivery, O 2 utilization, and systemic O 2 sensing. WIREs Syst Biol Med 2017, 9:e1382. doi: 10.1002/wsbm.1382 This article is categorized under: Biological Mechanisms > Metabolism Physiology > Mammalian Physiology in Health and Disease Physiology > Organismal Responses to Environment

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