Open AccessSystems biology of oxygen homeostasis
Author(s) -
Samanta Debangshu,
Prabhakar Nanduri R.,
Semenza Gregg L.
Publication year - 2017
Publication title -
wiley interdisciplinary reviews: systems biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.087
H-Index - 51
eISSN - 1939-005X
pISSN - 1939-5094
DOI - 10.1002/wsbm.1382
Subject(s) - homeostasis , hypoxia (environmental) , pathophysiology , biology , microbiology and biotechnology , oxygen delivery , gene , oxygen , bioinformatics , physiology , chemistry , genetics , endocrinology , organic chemistry
Metazoan species maintain oxygen homeostasis through the activity of hypoxia‐inducible factors, which are transcriptional activators that regulate the expression of hundreds of genes to match O 2 supply and demand. Here, we review the involvement of hypoxia‐inducible factors in the molecular physiology and pathophysiology of cellular O 2 sensing, O 2 delivery, O 2 utilization, and systemic O 2 sensing. WIREs Syst Biol Med 2017, 9:e1382. doi: 10.1002/wsbm.1382 This article is categorized under: Biological Mechanisms > Metabolism Physiology > Mammalian Physiology in Health and Disease Physiology > Organismal Responses to Environment