Open AccessSystems biology of polycystic kidney disease: a critical review
Author(s) -
Menezes Luis Fernando,
Germino Gregory G.
Publication year - 2015
Publication title -
wiley interdisciplinary reviews: systems biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.087
H-Index - 51
eISSN - 1939-005X
pISSN - 1939-5094
DOI - 10.1002/wsbm.1289
Subject(s) - polycystic kidney disease , disease , polycystic kidney , biology , medicine , kidney , endocrinology
The proliferation and diminishing costs of ‘omics’ approaches have finally opened the doors for small and medium laboratories to enter the ‘systems biology era’. This is a welcome evolution that requires a new framework to design, interpret, and validate studies. Here, we highlight some of the challenges, contributions, and prospects of the ‘cyst‐ems biology’ of polycystic kidney disease. WIREs Syst Biol Med 2015, 7:39–52. doi: 10.1002/wsbm.1289 This article is categorized under: Analytical and Computational Methods > Computational Methods Laboratory Methods and Technologies > Genetic/Genomic Methods Translational, Genomic, and Systems Medicine > Translational Medicine