Open AccessIntegrative modeling of the cardiac ventricular myocyte
Author(s) -
Winslow Raimond L.,
Cortassa Sonia,
O'Rourke Brian,
Hashambhoy Yasmin L.,
Rice John Jeremy,
Greenstein Joseph L.
Publication year - 2010
Publication title -
wiley interdisciplinary reviews: systems biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.087
H-Index - 51
eISSN - 1939-005X
pISSN - 1939-5094
DOI - 10.1002/wsbm.122
Subject(s) - cardiac myocyte , myocyte , context (archaeology) , neuroscience , cardiac electrophysiology , computer science , signal transduction , computational model , biology , electrophysiology , microbiology and biotechnology , artificial intelligence , paleontology
Cardiac electrophysiology is a discipline with a rich 50‐year history of experimental research coupled with integrative modeling which has enabled us to achieve a quantitative understanding of the relationships between molecular function and the integrated behavior of the cardiac myocyte in health and disease. In this paper, we review the development of integrative computational models of the cardiac myocyte. We begin with a historical overview of key cardiac cell models that helped shape the field. We then narrow our focus to models of the cardiac ventricular myocyte and describe these models in the context of their subcellular functional systems including dynamic models of voltage‐gated ion channels, mitochondrial energy production, ATP‐dependent and electrogenic membrane transporters, intracellular Ca dynamics, mechanical contraction, and regulatory signal transduction pathways. We describe key advances and limitations of the models as well as point to new directions for future modeling research. WIREs Syst Biol Med 2011 3 392–413 DOI: 10.1002/wsbm.122 This article is categorized under: Models of Systems Properties and Processes > Cellular Models