Open AccessCoupling of P2Y receptors to G proteins and other signaling pathways
Author(s) -
Erb Laurie,
Weisman Gary A.
Publication year - 2012
Publication title -
wiley interdisciplinary reviews: membrane transport and signaling
Language(s) - English
Resource type - Journals
eISSN - 2190-4618
pISSN - 2190-460X
DOI - 10.1002/wmts.62
Subject(s) - p2y receptor , microbiology and biotechnology , g protein coupled receptor , heterotrimeric g protein , receptor , signal transduction , chemistry , g protein , uridine diphosphate , biochemistry , biology , extracellular , purinergic receptor , enzyme
P2Y receptors are G protein‐coupled receptors (GPCRs) that are activated by adenine and uridine nucleotides and nucleotide sugars. There are eight subtypes of P2Y receptors (P2Y 1 , P2Y 2 , P2Y 4 , P2Y 6 , P2Y 11 , P2Y 12 , P2Y 13 , and P2Y 14 ), which activate intracellular signaling cascades to regulate a variety of cellular processes, including proliferation, differentiation, phagocytosis, secretion, nociception, cell adhesion, and cell migration. These signaling cascades operate mainly by the sequential activation or deactivation of heterotrimeric and monomeric G proteins, phospholipases, adenylyl and guanylyl cyclases, protein kinases, and phosphodiesterases. In addition, there are numerous ion channels, cell adhesion molecules, and receptor tyrosine kinases that are modulated by P2Y receptors and operate to transmit an extracellular signal to an intracellular response. WIREs Membr Transp Signal 2012, 1:789–803. doi: 10.1002/wmts.62 For further resources related to this article, please visit the WIREs website .