Open AccessThe two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies
Author(s) -
Tao Hirotaka,
Kawakami Yasuhiko,
Hui Chichung,
Hopyan Sevan
Publication year - 2017
Publication title -
wiley interdisciplinary reviews: developmental biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.779
H-Index - 45
eISSN - 1759-7692
pISSN - 1759-7684
DOI - 10.1002/wdev.270
Subject(s) - limb development , limb bud , anatomy , biology , phenotype , vertebrate , apical ectodermal ridge , bioinformatics , genetics , gene , embryogenesis , ectoderm
Functional annotation of mutations that cause human limb anomalies is enabled by basic developmental studies. In this study, we focus on the prepatterning stage of limb development and discuss a recent model that proposes anterior and posterior domains of the early limb bud generate two halves of the future skeleton. By comparing phenotypes in humans with those in model organisms, we evaluate whether this prepatterning concept helps to annotate human disease alleles. WIREs Dev Biol 2017, 6:e270. doi: 10.1002/wdev.270 This article is categorized under: Vertebrate Organogenesis > Musculoskeletal and Vascular Birth Defects > Organ Anomalies