Open AccessBuilding blocks of the cerebral cortex: from development to the dish
Author(s) -
Harris James,
Tomassy Giulio Srubek,
Arlotta Paola
Publication year - 2015
Publication title -
wiley interdisciplinary reviews: developmental biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.779
H-Index - 45
eISSN - 1759-7692
pISSN - 1759-7684
DOI - 10.1002/wdev.192
Subject(s) - cerebral cortex , neuroscience , cortex (anatomy) , biology , process (computing) , central nervous system , anatomy , computer science , operating system
Since Ramon y Cajal's examination of the cellular makeup of the cerebral cortex, it has been appreciated that this tissue exhibits some of the greatest degrees of cellular heterogeneity in the entire nervous system. This intricate structure emerges during a well‐choreographed developmental process. Here, we review current classifications of the cellular constituents of the cerebral cortex and examine how these building blocks are forged during development. We also look at how basic developmental features underlying cortex formation in vivo have been applied to protocols aimed at generating cortical tissue in vitro . WIREs Dev Biol 2015, 4:529–544. doi: 10.1002/wdev.192 This article is categorized under: Nervous System Development > Vertebrates: Regional Development Adult Stem Cells, Tissue Renewal, and Regeneration > Stem Cell Differentiation and Reversion