Open AccessWNT signaling in bone development and homeostasis
Author(s) -
Zhong Zhendong,
Ethen Nicole J.,
Williams Bart O.
Publication year - 2014
Publication title -
wiley interdisciplinary reviews: developmental biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.779
H-Index - 45
eISSN - 1759-7692
pISSN - 1759-7684
DOI - 10.1002/wdev.159
Subject(s) - wnt signaling pathway , homeostasis , organogenesis , bone resorption , microbiology and biotechnology , bone remodeling , biology , lrp5 , bone formation , signal transduction , lrp6 , endocrinology , medicine , genetics , gene
The balance between bone formation and bone resorption controls postnatal bone homeostasis. Research over the last decade has provided a vast amount of evidence that WNT signaling plays a pivotal role in regulating this balance. Therefore, understanding how the WNT signaling pathway regulates skeletal development and homeostasis is of great value for human skeletal health and disease. WIREs Dev Biol 2014, 3:489–500. doi: 10.1002/wdev.159 This article is categorized under: Vertebrate Organogenesis > Musculoskeletal and Vascular