Open AccessModel organism development and evaluation for late‐onset Alzheimer's disease: MODEL‐AD
Author(s) -
Oblak Adrian L.,
Forner Stefania,
Territo Paul R.,
Sasner Michael,
Carter Gregory W.,
Howell Gareth R.,
SukoffRizzo Stacey J.,
Logsdon Benjamin A.,
Mangravite Lara M.,
Mortazavi Ali,
BagliettoVargas David,
Green Kim N.,
MacGregor Grant R.,
Wood Marcelo A.,
Tenner Andrea J.,
LaFerla Frank M.,
Lamb Bruce T.
Publication year - 2020
Publication title -
alzheimer's and dementia: translational research and clinical interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.49
H-Index - 30
ISSN - 2352-8737
DOI - 10.1002/trc2.12110
Subject(s) - disease , dementia , clinical trial , intervention (counseling) , alzheimer's disease , medicine , precision medicine , organism , model organism , gerontology , psychology , biology , psychiatry , pathology , paleontology , biochemistry , gene
Alzheimer's disease (AD) is a major cause of dementia, disability, and death in the elderly. Despite recent advances in our understanding of the basic biological mechanisms underlying AD, we do not know how to prevent it, nor do we have an approved disease‐modifying intervention. Both are essential to slow or stop the growth in dementia prevalence. While our current animal models of AD have provided novel insights into AD disease mechanisms, thus far, they have not been successfully used to predict the effectiveness of therapies that have moved into AD clinical trials. The Model Organism Development and Evaluation for Late‐onset Alzheimer's Disease (MODEL‐AD; www.model-ad.org ) Consortium was established to maximize human datasets to identify putative variants, genes, and biomarkers for AD; to generate, characterize, and validate the next generation of mouse models of AD; and to develop a preclinical testing pipeline. MODEL‐AD is a collaboration among Indiana University (IU); The Jackson Laboratory (JAX); University of Pittsburgh School of Medicine (Pitt); Sage BioNetworks (Sage); and the University of California, Irvine (UCI) that will generate new AD modeling processes and pipelines, data resources, research results, standardized protocols, and models that will be shared through JAX's and Sage's proven dissemination pipelines with the National Institute on Aging–supported AD Centers, academic and medical research centers, research institutions, and the pharmaceutical industry worldwide.