Open AccessCriteria for the selection of radiation accident victims for stem cell transplantation
Author(s) -
Densow Dirk,
Kindler Hauke,
Fliedner Theodor M.,
Baranov Alexander E.,
Tibken Bernd,
Hofer Eberhard P.
Publication year - 1997
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1002/stem.5530150738
Subject(s) - biology , selection (genetic algorithm) , transplantation , stem cell , genetics , medicine , artificial intelligence , computer science
The management of acute radiation syndrome in persons inadvertently exposed to totalbody irradiation greatly benefits from the experience gained in previous clinical management situations. Within the framework of exposure to high doses, one of the most critical issues is the question of whether hematopoietic stem cell transplantation is indicated. A valid answer can be given with appropriate accuracy based on a thorough analysis and evaluation of all accessible case histories. Based on the clinical evaluation of patients severely affected with acute radiation syndrome, the following recommendations may be issued. There is limited indication for stem cell transplantation when there is accompanying severe radiation damage to organ systems other than the hematopoietic system. The optimum duration of pancytopenia can be estimated using the biomathematical model introduced in this article. Stem Cells 1997; 15 (suppl 2): 287‐297