Open AccessConcise Review: Forkhead Pathway in the Control of Adult Neurogenesis
Author(s) -
Genin Emmanuelle C.,
Caron Nicolas,
Vandenbosch Renaud,
Nguyen Laurent,
Malgrange Brigitte
Publication year - 2014
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1002/stem.1673
Subject(s) - neurogenesis , subgranular zone , biology , dentate gyrus , neural stem cell , neuroscience , hippocampus , lateral ventricles , stem cell , transcription factor , microbiology and biotechnology , subventricular zone , genetics , gene
New cells are continuously generated from immature proliferating cells in the adult brain in two neurogenic niches known as the subgranular zone (SGZ) of the dentate gyrus (DG) of the hippocampus and the sub‐ventricular zone (SVZ) of the lateral ventricles. However, the molecular mechanisms regulating their proliferation, differentiation, migration and functional integration of newborn neurons in pre‐existing neural network remain largely unknown. Forkhead box (Fox) proteins belong to a large family of transcription factors implicated in a wide variety of biological processes. Recently, there has been accumulating evidence that several members of this family of proteins play important roles in adult neurogenesis. Here, we describe recent advances in our understanding of regulation provided by Fox factors in adult neurogenesis, and evaluate the potential role of Fox proteins as targets for therapeutic intervention in neurodegenerative diseases. S tem C ells 2014;32:1398–1407