Open AccessEfficient β‐cell regeneration by a combination of neogenesis and replication following β‐cell ablation and reversal of pancreatic duct ligation
Author(s) -
Hao Ergeng,
Lee SeungHee,
Levine Fred
Publication year - 2013
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1002/stem.1492
Subject(s) - neogenesis , biology , ligation , regeneration (biology) , microbiology and biotechnology , cell , stem cell , mesenchymal stem cell , endocrinology , insulin , genetics , islet
A bstract Achieving efficient β‐cell regeneration is a major goal of diabetes research. Previously, we found that a combination of β‐cell ablation and pancreatic duct ligation led to β‐cell regeneration by direct conversion from α‐cells. Here, we studied the effect of surgical reversal of the duct ligation, finding that there was a wave of β‐cell replication following reversal. The combination of β‐cell neogenesis prior to reversal of the duct ligation and β‐cell replication following reversal resulted in efficient β‐cell regeneration and eventual recovery of function. This provides an important proof of principle that efficient β‐cell regeneration is possible, even from a starting point of profound β‐cell ablation. This has important implications for efforts to promote β‐cell regeneration. S tem C ells 2013;31:2388–2395