Open AccessThe effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells
Author(s) -
Grimm Daniela,
Wehland Markus,
Corydon Thomas J.,
Richter Peter,
Prasad Binod,
Bauer Johann,
Egli Marcel,
Kopp Sascha,
Lebert Michael,
Krüger Marcus
Publication year - 2020
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.1002/sctm.20-0084
Subject(s) - cancer stem cell , stem cell , cancer cell , cancer , cancer research , biology , cellular differentiation , metastasis , regenerative medicine , microbiology and biotechnology , immunology , genetics , gene
A spaceflight has enormous influence on the health of space voyagers due to the combined effects of microgravity and cosmic radiation. Known effects of microgravity (μ g ) on cells are changes in differentiation and growth. Considering the commercialization of spaceflight, future space exploration, and long‐term manned flights, research focusing on differentiation and growth of stem cells and cancer cells exposed to real (r‐) and simulated (s‐) μ g is of high interest for regenerative medicine and cancer research. In this review, we focus on platforms to study r‐ and s‐μ g as well as the impact of μ g on cancer stem cells in the field of gastrointestinal cancer, lung cancer, and osteosarcoma. Moreover, we review the current knowledge of different types of stem cells exposed to μ g conditions with regard to differentiation and engineering of cartilage, bone, vasculature, heart, skin, and liver constructs.