Open AccessPerspective on human pluripotent stem cell‐derived cardiomyocytes in heart disease modeling and repair
Author(s) -
Li Qiang,
Wang Jia,
Wu Qiang,
Cao Nan,
Yang HuangTian
Publication year - 2020
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.1002/sctm.19-0340
Subject(s) - induced pluripotent stem cell , disease , stem cell , human heart , heart disease , neuroscience , medicine , bioinformatics , human induced pluripotent stem cells , stem cell biology , computational biology , biology , pathology , embryonic stem cell , cardiology , microbiology and biotechnology , gene , genetics , reproductive technology , embryogenesis
Heart diseases (HDs) are the leading cause of morbidity and mortality worldwide. Despite remarkable clinical progress made, current therapies cannot restore the lost myocardium, and the correlation of genotype to phenotype of many HDs is poorly modeled. In the past two decades, with the rapid developments of human pluripotent stem cell (hPSC) biology and technology that allow the efficient preparation of cardiomyocytes from individual patients, tremendous efforts have been made for using hPSC‐derived cardiomyocytes in preclinical and clinical cardiac therapy as well as in dissection of HD mechanisms to develop new methods for disease prediction and treatment. However, their applications have been hampered by several obstacles. Here, we discuss recent advances, remaining challenges, and the potential solutions to advance this field.