Open AccessProgress in the Use of Induced Pluripotent Stem Cell‐Derived Neural Cells for Traumatic Spinal Cord Injuries in Animal Populations: Meta‐Analysis and Review
Author(s) -
Ramotowski Christina,
Qu Xianggui,
VillaDiaz Luis G.
Publication year - 2019
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.1002/sctm.18-0225
Subject(s) - induced pluripotent stem cell , embryonic stem cell , neural stem cell , neuroscience , spinal cord injury , spinal cord , stem cell , somatic cell , regenerative medicine , medicine , biology , microbiology and biotechnology , genetics , gene
Induced pluripotent stem cells (iPSCs) are cells genetically reprogrammed from somatic cells, which can be differentiated into neurological lineages with the aim to replace or assist damaged neurons in the treatment of spinal cord injuries (SCIs) caused by physical trauma. Here, we review studies addressing the functional use of iPSC‐derived neural cells in SCIs and perform a meta‐analysis to determine if significant motor improvement is restored after treatment with iPSC‐derived neural cells compared with treatments using embryonic stem cell (ESC)‐derived counterpart cells and control treatments. Overall, based on locomotion scales in rodents and monkeys, our meta‐analysis indicates a therapeutic benefit for SCI treatment using neural cells derived from either iPSCs or ESCs, being this of importance due to existing ethical and immunological complications using ESCs. Results from these studies are evidence of the successes and limitations of iPSC‐derived neural cells in the recovery of motor capacity. Stem Cells Translational Medicine 2019;8:681&693