Open AccessTurning Potential Into Action: Using Pluripotent Stem Cells to Understand Heart Development and Function in Health and Disease
Author(s) -
Fonoudi Hananeh,
Bosman Alexis
Publication year - 2017
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.1002/sctm.16-0476
Subject(s) - induced pluripotent stem cell , stem cell , action (physics) , function (biology) , disease , biology , neuroscience , microbiology and biotechnology , medicine , computational biology , bioinformatics , embryonic stem cell , genetics , physics , gene , quantum mechanics
Summary Pluripotent stem cells hold enormous potential for regenerative therapies, however their ability to provide insight into early human development and the origins of disease could arguably provide an even greater outcome. This is primarily due to their contribution to the establishment of a powerful knowledge base of human development, something which all researchers and clinicians can potentially benefit from. Modeling human heart development and disease using pluripotent stem cells has already provided many important insights into cardiogenesis and cardiovascular disease mechanisms however, it is important to be aware of the complexities of this model system. Thorough contemplation of experimental models and specialized techniques is required to provide high‐quality evidence of the intricacies of both normal early development, and when this process goes awry in disease states. S tem C ells T ranslational M edicine 2017;6:1452–1457