Open AccessThe use of phosphorus oxychloride in the synthesis of amino acid p‐nitroanilides
Author(s) -
Rijkers D. T. S.,
Hemker H. C.,
Nefkens G. H. L.,
Tesser G. I.
Publication year - 1991
Publication title -
recueil des travaux chimiques des pays‐bas
Language(s) - English
Resource type - Journals
ISSN - 0165-0513
DOI - 10.1002/recl.19911100709
Subject(s) - racemization , chemistry , phosphorus , condensation , amino acid , organic chemistry , combinatorial chemistry , biochemistry , thermodynamics , physics
Phosphorus oxychloride is described as a condensing agent in the preparation of nitroanilides. The condensation was free of racemization with amino acid derivatives of the urethane type and the current amino protective groups can be applied. The yields are high to excellent.
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