Open AccessSynthesis and biological activity of four analogues of β‐corticotropin
Author(s) -
Tesser G.I.,
Buis J.T.
Publication year - 1971
Publication title -
recueil des travaux chimiques des pays‐bas
Language(s) - English
Resource type - Journals
ISSN - 0165-0513
DOI - 10.1002/recl.19710900415
Subject(s) - amide , biological activity , chemistry , stereochemistry , medicine , biochemistry , in vitro
The syntheses of four ACTH‐analogues: [Orn 15‐18 ]‐, [ D Ser 1 , Orn 15‐18 ]‐, [Orn 11‐15‐18 ]‐ and [ D Ser 1 , Orn 11,15‐18 ]‐β‐corticotropin‐(1‐18)‐octadecapeptide amide** are described. The last mentioned compound exhibits an unexpected, strongly prolonged, biological activity. A possible explanation is given.
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