Open AccessPost‐coronavirus disease 2019 organizing pneumonia confirmed pathologically by video‐assisted thoracoscopic surgery
Author(s) -
Sugino Keishi,
Ono Hirotaka,
Haraguchi Shuji,
Igarashi Seiji,
Hebisawa Akira,
Tsuboi Eiyasu
Publication year - 2021
Publication title -
respirology case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 9
ISSN - 2051-3380
DOI - 10.1002/rcr2.871
Subject(s) - medicine , pneumonia , covid-19 , video assisted thoracoscopic surgery , lung , pulmonary fibrosis , nintedanib , diffuse alveolar damage , fibrosis , organizing pneumonia , disease , surgery , idiopathic pulmonary fibrosis , infectious disease (medical specialty) , acute respiratory distress
Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2, has become a global pandemic. Many survivors of serious COVID‐19 pneumonia have long‐term residual pulmonary disease. However, there is little documentation of the histopathological characteristics of lung sequelae post‐COVID‐19 and effective treatments. We present two Japanese cases of lung sequelae post‐COVID‐19. The patients were histopathologically diagnosed with organizing pneumonia (OP) or OP with fibrosis and no diffuse alveolar damage on video‐assisted thoracoscopic surgery. Case 1, who had been diagnosed with OP, was successfully treated with corticosteroid and other immunosuppressive agents over a 6‐month period. Although case 2, who had been diagnosed with OP with fibrosis, had a partial and unsatisfactory response to immunosuppressive agents, the patient responded to antifibrotic treatment including nintedanib.