Open AccessFluorous 2,4‐Dichloro‐1,3,5‐triazines (F‐DCTs) as Nucleophile Scavengers
Author(s) -
Lu Yimin,
Zhang Wei
Publication year - 2006
Publication title -
qsar & combinatorial science
Language(s) - English
Resource type - Journals
eISSN - 1611-0218
pISSN - 1611-020X
DOI - 10.1002/qsar.200640042
Subject(s) - nucleophile , chemistry , triazine , solid phase extraction , extraction (chemistry) , ring (chemistry) , phase (matter) , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis
1 H ,1 H ,2 H ,2 H ,3 H ,3 H ‐perfluoroundecanol‐ and 1 H ,1 H ,2 H ,2 H ‐perfluorodecanethiol‐displaced 2,4‐dichloro‐1,3,5‐triazines 1 and 2 are synthesized and used as nucleophile scavengers to remove thiols and amines from solution‐phase reactions. Two active sites on the triazine ring are able to remove two equivalents of nucleophiles. The purification of reaction mixtures is accomplished by plate‐to‐plate fluorous solid‐phase extraction or automated solid‐phase extraction on the RapidTrace system.