Open AccessFluorous 2,4‐Dichloro‐1,3,5‐triazine (F‐DCT) as an Amide Coupling Agent
Author(s) -
Zhang Wei,
Lu Yimin
Publication year - 2006
Publication title -
qsar & combinatorial science
Language(s) - English
Resource type - Journals
eISSN - 1611-0218
pISSN - 1611-020X
DOI - 10.1002/qsar.200640041
Subject(s) - amide , triazine , chemistry , ring (chemistry) , extraction (chemistry) , condensation , condensation reaction , combinatorial chemistry , polymer chemistry , medicinal chemistry , organic chemistry , stereochemistry , catalysis , thermodynamics , physics
1 H ,1 H ,2 H ,2 H ,3 H ,3 H ‐perfluoroundecanol displaced 2,4‐dichloro‐1,3,5‐triazine 5 is synthesized and used as a condensation agent for amide synthesis. Two active sites on the triazine ring lead to formation of two equivalents of amidation products. The purification of reaction mixtures is accomplished by plate‐to‐plate fluorous solid‐phase extraction.