Open AccessAnalgesic effects of medicinal plants and phytochemicals on chemotherapy‐induced neuropathic pain through glial modulation
Author(s) -
Lee Ji Hwan,
Kim Nari,
Park Sangwon,
Kim Sun Kwang
Publication year - 2021
Publication title -
pharmacology research and perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.975
H-Index - 27
ISSN - 2052-1707
DOI - 10.1002/prp2.819
Subject(s) - medicine , analgesic , nausea , neuropathic pain , vomiting , gabapentin , medicinal plants , somnolence , side effect (computer science) , pharmacology , chemotherapy , adverse effect , traditional medicine , anesthesia , alternative medicine , pathology , computer science , programming language
Chemotherapy‐induced peripheral neuropathy (CIPN) frequently occurs in cancer patients. This side effect lowers the quality of life of patients and may cause the patients to abandon chemotherapy. Several medications (e.g., duloxetine and gabapentin) are recommended as remedies to treat CIPN; however, usage of these drugs is limited because of low efficacy or side effects such as dizziness, nausea, somnolence, and vomiting. From ancient East Asia, the decoction of medicinal herbal formulas or single herbs have been used to treat pain and could serve as alternative therapeutic option. Recently, the analgesic potency of medicinal plants and their phytochemicals on CIPN has been reported, and a majority of their effects have been shown to be mediated by glial modulation. In this review, we summarize the analgesic efficacy of medicinal plants and their phytochemicals, and discuss their possible mechanisms focusing on glial modulation in animal studies.