A turn‐off fluorescent substrate for horseradish peroxidase improves the sensitivity of  ELISA s | Zendy

Acharya Abhinav P. | Zendy; Sen Payel | Zendy; Aran Kiana | Zendy; Gardner Austin B. | Zendy; Rafi Mohammad | Zendy; Dean Deborah | Zendy; Murthy Niren | Zendy

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A turn‐off fluorescent substrate for horseradish peroxidase improves the sensitivity of ELISA s

Author(s) -

Acharya Abhinav P.,

Sen Payel,

Aran Kiana,

Gardner Austin B.,

Rafi Mohammad,

Dean Deborah,

Murthy Niren

Publication year - 2014

Publication title -

journal of polymer science part a: polymer chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.768

H-Index - 152

eISSN - 1099-0518

pISSN - 0887-624X

DOI - 10.1002/pola.27376

Subject(s) - horseradish peroxidase , substrate (aquarium) , fluorescence , peroxidase , chemistry , sensitivity (control systems) , enzyme , turn (biochemistry) , substrate specificity , combinatorial chemistry , biophysics , biochemistry , biology , optics , ecology , physics , electronic engineering , engineering

A new turn‐off fluorescent substrate for horseradish peroxidase is introduced, termed clics, which enhances the sensitivity of commercial enzyme‐linked immunosorbant assays (ELISA) by 32‐fold and detects chlamydial infections in patients. Clics are cost‐effective, stable, and can be easily incorporated in commercial ELISA kits, and therefore should have a great impact in the fields of medicine and biology.

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