Design and synthesis of new cationic water‐soluble pyrene containing dendrons for DNA sensory applications | Zendy

Chen ChingYi | Zendy; Ito Yumiko | Zendy; Chiu YuCheng | Zendy; Wu WenChung | Zendy; Higashihara Tomoya | Zendy; Ueda Mitsuru | Zendy; Chen WenChang | Zendy

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Design and synthesis of new cationic water‐soluble pyrene containing dendrons for DNA sensory applications

Author(s) -

Chen ChingYi,

Ito Yumiko,

Chiu YuCheng,

Wu WenChung,

Higashihara Tomoya,

Ueda Mitsuru,

Chen WenChang

Publication year - 2011

Publication title -

journal of polymer science part a: polymer chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.768

H-Index - 152

eISSN - 1099-0518

pISSN - 0887-624X

DOI - 10.1002/pola.25031

Subject(s) - pyrene , cationic polymerization , dendrimer , chemistry , aqueous solution , fluorescence , polymer chemistry , dna , photochemistry , combinatorial chemistry , organic chemistry , biochemistry , physics , quantum mechanics

A series of new water‐soluble cationic pyrene‐dendron derivatives, G1 , G2 , and G3, was successfully synthesized and characterized. These new dendrons were designed with the quaternized amino moieties at the periphery of the dendrons for DNA detection and functionalized with pyrene as a fluorescent probe. The electrostatic interactions between the plasmid DNA (pDNA) and cationic charged dendrons in an aqueous solution resulted in a change in the photophysical properties of pyrene, which could be shown in the UV‐vis and fluorescence spectra. Pyrene dendrons showed a high and rapid fluorescence response upon the addition of pDNA, which was strongly dependent on the size and hydrophobicity of the dendrons. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012

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